Fig. 1
From: Impaired glucose metabolism and altered gut microbiome despite calorie restriction of ob/ob mice
Body composition monitored from week 2, approximately every second week for 7 weeks. a-b Body weight development (a) and absolute weight gain (b). c-d Fat mass in grams (c) and absolute change in fat mass (d). e-f Fat mass as percentage of body weight (e) and absolute change in fat mass percentage (f). g-h Lean body mass in grams (g) and absolute change in lean body mass (h). i-j Lean mass as percentage of body weight (i) and absolute change in lean mass percentage (j). k Absolute blood glucose levels before and after oral glucose administration during oral glucose tolerance test conducted in week 10. Both OB-PF-vs-OB and OB-PF-vs-WT comparisons have statistically significant differences (P < 0.01) following one-way ANOVA. Statistical significance from multiple comparison test following two-way repeated measures ANOVA are shown using letter-based codes: within each time point, pairs of groups that do not share a letter show statistically significant (P < 0.05) difference. See Additional file 4: Table S9 for all comparisons. l Area under the curve above baseline blood glucose of individual groups. m-n Plasma insulin concentration 60 min before and 15 min after glucose was administered orally (m) and increase in plasma insulin (n). Comparisons with statistically significant differences are denoted with significance levels as: ***P < 0.001, **P < 0.01, *P < 0.05