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Fig. 5 | Animal Microbiome

Fig. 5

From: The microbiota of healthy dogs demonstrates individualized responses to synbiotic supplementation in a randomized controlled trial

Fig. 5

Varying degrees of PCoA4 changes from week 0 to week 4 were observed among subjects receiving the synbiotic supplement. a PCoA4 score at week 4 increased in 20 dogs (87%) as compared to baseline in the synbiotic group, while the direction of change was less consistent in the placebo (PL) group - increased in 11 dogs (58%) and decreased in 8 dogs (42%). Subjects in the synbiotic group were divided into tertiles based on the degree of PCoA4 changes between week 0 and week 4, with subjects in the first tertile labeled high-responders (HR, maximal PCoA4 score increase, n = 8), those in the second tertile mid-responders (MR, n = 7), and those in the third tertile low-responders (LR, PCoA4 score decrease or minimal PCoA4 score increase, n = 8). b PCoA4 scores at week 4 were significantly higher in HR (0.132 ± 0.037, FDR-adjusted p = 0.003, pairwise Wilcoxon rank sum test) and MR (0.091 ± 0.076, FDR-adjusted p = 0.043) as compared to LR (−0.004 ± 0.080). c PCoA3 scores were significantly higher in HR (0.084 ± 0.117) than LR (−0.043 ± 0.049) but not MR (− 0.038 ± 0.096) at baseline (FDR-adjusted p = 0.031, Kruskal-Wallis test). PCoA3 scores were not significantly different among groups at week 4 or week 6

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