Table 2 Kyoto Encyclopedia of Genes and Genomes Orthology (KO) terms with significant increase or decrease in the differential abundance analysis (|fold change| ≥ 2 and adjusted p < 0.05) at week 4 or 6 relative to week 0

K18364

2-oxopent-4-enoate/cis-2-oxohex-4-enoate hydratase

6.69 ± 0.91

8.30E-10

–

NS

–

NS

K16001

narbonolide/10-deoxymethynolide synthase

5.03 ± 0.87

1.23E-05

–

NS

–

NS

K16147

starch synthase (maltosyl-transferring)

4.11 ± 0.98

1.14E-02

–

NS

–

NS

K00689

dextransucrase

4.06 ± 0.89

3.91E-03

–

NS

–

NS

K01621

xylulose-5-phosphate/fructose-6-phosphate phosphoketolase

3.94 ± 0.89

5.22E-03

–

NS

–

NS

K16323

purine nucleoside transport protein

3.76 ± 0.85

5.22E-03

–

NS

–

NS

K16869

octanoyl-[GcvH]:protein N-octanoyltransferase

3.66 ± 0.75

1.20E-03

–

NS

–

NS

K20510

malonyl-S-ACP:biotin-protein carboxyltransferase subunit MadC

3.62 ± 0.76

1.70E-03

–

NS

–

NS

K20708

isoleucine 2-epimerase

3.61 ± 0.87

1.27E-02

–

NS

–

NS

K03378

morphine 6-dehydrogenase

3.49 ± 0.79

5.22E-03

–

NS

–

NS

K13929

malonate decarboxylase alpha subunit

3.07 ± 0.75

1.46E-02

–

NS

–

NS

K01699

propanediol dehydratase large subunit

2.66 ± 0.67

2.09E-02

–

NS

–

NS

K10556

AI-2 transport system permease protein

1.80 ± 0.48

3.85E-02

–

NS

–

NS

K06042

precorrin-8X/cobalt-precorrin-8 methylmutase

1.69 ± 0.46

4.83E-02

–

NS

–

NS

K00841

aminotransferase

1.23 ± 0.31

2.08E-02

–

NS

–

NS

K15521

D-inositol-3-phosphate glycosyltransferase

−2.13 ± 0.57

4.31E-02

–

NS

–

NS

K11384

two-component system, NtrC family, response regulator AlgB

−1.87 ± 0.51

4.67E-02

–

NS

–

NS

K15629

CYP152A; fatty-acid peroxygenase [EC:1.11.2.4]

–

NS

–

NS

5.10 ± 1.14

7.41E-06

K16139

glucuronide carrier protein

–

NS

–

NS

−4.62 ± 1.07

2.76E-02