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Table 3 Differentially enriched metagenome functions recovered from LEfSe analysis

From: You are more than what you eat: potentially adaptive enrichment of microbiome functions across bat dietary niches

MetaCyc Pathway

Superpathway

Enrichment

LDA Score

Wilcoxon P

DTDPHRAMSYN_PWY

Carbohydrate Biosynthesis

Herbivorous

2.92

1.27E−14

OANTIGEN-PWY

Carbohydrate Biosynthesis

Herbivorous

2.90

8.91E−15

SALVADEHYPOX-PWY

Nucleoside and Nucleotide Degradation

Herbivorous

2.76

2.10E−07

†PWY-7111

Engineered

Herbivorous

2.74

6.98E−09

P125-PWY

Other Biosynthesis

Herbivorous

2.69

7.95E−20

PWY-6471

Cell Structure Biosynthesis

Herbivorous

2.69

8.12E−07

PWY-6353

Nucleoside and Nucleotide Degradation

Herbivorous

2.66

6.18E−07

LACTOSECAT-PWY

Carbohydrate Degradation

Herbivorous

2.64

1.40E−13

*PWY-5101

Amino Acid Biosynthesis

Herbivorous

2.63

1.10E−07

BRANCHED-CHAIN-AA-SYN-PWY

Amino Acid Biosynthesis

Herbivorous

2.62

3.68E−09

*PWY-5103

Amino Acid Biosynthesis

Herbivorous

2.61

2.09E−09

*ILEUSYN-PWY

Amino Acid Biosynthesis

Herbivorous

2.61

8.36E−08

*VALSYN-PWY

Amino Acid Biosynthesis

Herbivorous

2.61

8.36E−08

P124-PWY

Fermentation

Herbivorous

2.59

3.39E−09

*TRPSYN-PWY

Amino Acid Biosynthesis

Herbivorous

2.58

7.93E−07

*HSERMETANA-PWY

Amino Acid Biosynthesis

Herbivorous

2.58

1.23E−06

GLYCOCAT-PWY

Polymeric Compound Degradation

Herbivorous

2.55

7.96E−06

PWY-6612

Cofactor, Prosthetic Group, Electron Carrier, and Vitamin Biosynthesis

Herbivorous

2.54

7.51E−09

PWY-6737

Polymeric Compound Degradation

Herbivorous

2.53

2.33E−05

PWY-6608

Nucleoside and Nucleotide Degradation

Herbivorous

2.52

8.16E−05

PWY-7431

Amine and Polyamine Degradation

Herbivorous

2.50

3.29E−08

GLYCOGENSYNTH-PWY

Carbohydrate Biosynthesis

Herbivorous

2.50

1.83E−05

HEMESYN-PWY

Cofactor, Prosthetic Group, Electron Carrier, and Vitamin Biosynthesis

Animalivorous

2.50

0.0165

PWY-6895

Cofactor, Prosthetic Group, Electron Carrier, and Vitamin Biosynthesis

Animalivorous

2.51

9.74E−09

PWY-5100

Fermentation

Animalivorous

2.52

0.013

PWY0-1241

Carbohydrate Biosynthesis

Animalivorous

2.55

1.68E−06

PWY-6467

Cell Structure Biosynthesis

Animalivorous

2.55

0.00052

PWY-5973

Fatty Acid and Lipid Biosynthesis

Animalivorous

2.55

1.88E−05

NAGLIPASYN-PWY

Cell Structure Biosynthesis

Animalivorous

2.58

6.92E−05

PWY-7560

Secondary Metabolite Biosynthesis

Animalivorous

2.58

0.00044074

NONMEVIPP-PWY

Secondary Metabolite Biosynthesis

Animalivorous

2.58

0.0004

PWY-1269

Carbohydrate Biosynthesis

Animalivorous

2.59

5.64E−05

*PWY-5097

Amino Acid Biosynthesis

Animalivorous

2.61

0.0004

PWY-6892

Cofactor, Prosthetic Group, Electron Carrier, and Vitamin Biosynthesis

Animalivorous

2.64

3.33E−08

PWY-6891

Cofactor, Prosthetic Group, Electron Carrier, and Vitamin Biosynthesis

Animalivorous

2.66

1.09E−09

PWY-7663

Fatty Acid and Lipid Biosynthesis

Animalivorous

2.70

2.92E−09

FASYN-ELONG-PWY

Fatty Acid and Lipid Biosynthesis

Animalivorous

2.78

3.86E−09

  1. All LDA scores were retained only where LDA ≥ 2.5 and are shown rounded to the second decimal place. Wilcoxon test was considered to be significant if P ≤ 0.05. † is an engineered metabolic pathway, while * notes a synthesis pathway for an essential or conditionally essential amino acid