Fig. 6

Significant associations between sample metadata and microbial clades in the mucosa. a Heatmap summarizing significant associations between sample metadata and microbial clades in the mucosa. Color key: − log(q value) *sign(coefficient). Cells that denote significant associations are colored in red or blue and overlaid with a plus (+) or minus (−) sign that indicates the direction of association: Diet (+), higher relative abundance in salmon fed the insect meal diet; Segment (+), higher relative abundance in the distal intestine; foxp3 (+)/plin2 (+), positive correlation between microbial clade relative abundance and gene expression levels. b Representative taxa showing higher relative abundances in salmon fed the reference diet. c Representative taxa showing higher relative abundances in salmon fed the insect meal diet. d Positive correlation between the relative abundance of Paenibacillus and foxp3 expression levels in the intestine. e Negative correlation between the relative abundance of Enterococcus and plin2 expression levels in the intestine. The relative abundances of representative taxa in the feeds are shown as grey dots in b, c. Taxa not assigned at the genus level are prepended with letters indicating whether the taxonomic assignment was made at the phylum(p_), order (o_), or family (f_) level. REF, reference diet; IM, insect meal diet; PI, proximal intestine; DI, distal intestine; FDR, false discovery rate; N.not.zero, number of observations that are not zero