Genome-wide mapping of gene-microbe interactions in the murine lung microbiota based on quantitative microbial profiling

Table 2 List of candidate genes within confidence intervals and their functions

	Trait	Gene	Functions (& references)
RA	Enterobacteriaceae / Enterobacteriales	Chrnd, Chrng	Nicotine dependence, smoking behaviors, lung cancer, COPD [66]; lung hypoplasia [67]
		Ecel1	Restrictive lung disease (affected by respiratory muscles) [68]
		Dis3l2	Lung function [69]
		Kcnj13	Development & physiology of the respiratory system [70]; tracheal tubulogenesis [71]
QMP	Deltaprotebacteria	Per2	NSCLC [72, 73]; lung tumorigenesis [74]
		Twist2	Lung cancer [75]; lung adenocarcinoma [76]; Pneumonia [77]
	Pelomonas	Ptchd3	Asthma [78]
	Streptococcus	Grik1	Lung metastasis (of colorectal cancer in vivo) [79]; lung cancer [80]
		Bach1	Lung cancer [81,82,83]; cystic fibrosis [84]
		Map3k7cl	NSCLC [85]; pulmonary cell development [86]
	ASV8_Propionibacterium	Nalcn	Respiratory rhythm [87]; NSCLC [88]
		Fgf14	Lung Adenocarcinomas [89, 90]; lung functioning & phenotype [91]
		Ubac2	COPD [92]; cystic fibrosis [93]; asthma [94]
		Zic2	Lung adenocarcinoma [95]; NSCLC [96]; SCLC [97, 98]
ddPCR-DNA	Lactobacillus	Mk2	Lung cancer [99]; inflammatory pulmonary diseases [100]
		Il10	Tuberculosis [101]; asthma [102]; NSCLC [103, 104]
		Il19	Antimicrobial defense in airway epithelial cells [105]
		pIgR	COPD-like phenotype airway inflammation [106]
ddPCR-RNA	Pelomonas	Pou3f2	NSCLC [63]
		Mms22l	Lung carcinogenesis [64]
		Klhl32	COPD [65]
		Fut9	Bronchopulmonary dysplasia [107]

Key: COPD: chronic obstructive pulmonary disorder, NSCLC: non-small cell lung cancer, SCLC: small cell lung cancer

ISSN: 2524-4671