Fig. 6
Effects of IMM ceftiofur treatment on the fecal resistome of cattle. Boxplots show the abundance score for genes encoding A) resistance to cephalosporins; and B) β-lactamases conferring resistance to cephalosporins. C) Differentially abundant ARGs are shown after ceftiofur treatment with the mean fold-change and standard error per group. The median, lower, and upper quartiles are shown in each boxplot with the whiskers representing extreme values in the distribution. P-values were calculated using the paired Wilcoxon signed rank test to compare treatment groups within a sampling point and between sampling points within the same treatment group; significant p-values are shown for all cows (black), control cows (grey), and cows treated with ceftiofur (orange)